Does Medicare Cover Linezolid?

In this article...
  • Linezolid is an antibiotic that treats bacterial infections, including pneumonia and skin infections. Learn whether linezolid is covered under Medicare.

Linezolid is a critical antibiotic in the treatment of bacterial infections and pneumonia, and it's covered by 100% of Medicare prescription drug plans when medically necessary. Learn more about linezolid and its costs to Medicare beneficiaries.

Basic Drug Information for Linezolid

Linezolid, the generic form of Zyvox, is a medication in a class known as oxazolidinone antibiotics. The drug works by preventing the growth of bacteria. It's used to treat bacterial infections, pneumonia and certain types of skin infections.

It's important to note that the drug is not effective against viral infections or the flu. Linezolid is available in tablet form, oral suspension and IV infusion.

Typically, the course of treatment with this drug ranges from 10 to 28 days. As with any antibiotic, it's important to complete the course of treatment even if you begin to feel better.

The most common side effects experienced with this drug are diarrhea, headache, nausea, vomiting and stomach pain. In some cases, individuals may experience white spots in the mouth, itching or burning sensations in the vagina, skin rash or dizziness.

It's important to let your doctor know if these symptoms develop or become severe. When taking this drug, you should avoid ingesting foods high in tyramine, such as alcoholic beverages, smoked or fermented foods and aged cheeses. 

How Much Does Linezolid Cost?

Once the deductible for Medicare Part D coverage is met for the year, the cost of linezolid while in the initial coverage stage ranges from $1 to $69, according to For 2022, the Medicare deductible is $480. After the initial coverage stage, the cost of linezolid will be higher in the Medicare donut hole. You may qualify for prescription drug cost assistance that will reduce or eliminate your out-of-pocket costs.

Are There Any Restrictions on Coverage for Linezolid?

Some Medicare prescription drug plans may have a quantity limit for linezolid. Additionally, coverage for linezolid in IV form, instead of oral formulations, may differ for Medicare beneficiaries. While Part D provides coverage for the drug itself, the administration of the medication via IV is separately covered under Part B benefits.

Beneficiaries should be aware that additional cost shares may apply for the administration of IV-infused medications, including IV antibiotics.

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