Does Medicare Cover Ceftriaxone?

Christian Worstell
In this article...
  • When afflicted with a bacterial infection, antibiotics are usually necessary. One of the most effective broad-spectrum antibiotics used is Ceftriaxone. Find out more.

Sepsis, pneumonia and meningitis are examples of bacterial infections that can occur in the human body at any stage of life. To combat them effectively, it’s necessary to use the right antibiotic. One of the best-known broad-spectrum antibiotics is Ceftriaxone, also known by its trade name Rocephin.

When Does Medicare Pay for Ceftriaxone?

Medicare Advantage (Medicare Part C) plans that include drug coverage and Medicare Part D prescription drug plans may cover the use of Ceftriaxone. Consult your specific Medicare insurance plan to determine whether the drug is covered for you and how much it costs.

You can also consult your plan formulary (or list of drugs) to find out how Ceftriaxone might be covered by your plan.

How Does Ceftriaxone Work?

Ceftriaxone is an injectable that’s applied to a vein or muscle. It’s used to fend off excessive bacteria and prevent infections from proliferating. Ceftriaxone is effective for up to 6 weeks, depending on the type of infection. It’s often used to treat dozens of infections in various parts of the body, including:

  • Blood infections
  • Abdominal infections
  • Lung infections
  • Infections in the brain
  • Infections in the bone and joints

Ceftriaxone is also often effective against gonorrhea, a sexually transmitted disease, and infections that can occur after surgery.

Ceftriaxone Side Effects

In clinical studies done with Ceftriaxone, the most common side effects experienced by users of the drug were upset stomach and diarrhea. Some patients also experienced rashes at the injection site.

Other rare side effects include:

  • Increased liver enzymes, which may indicate liver damage
  • Reduction of platelets, which can compromise blood clotting
  • Reduction of white blood cells
  • Eosinophilia, which means an increase in a specific type of white blood cell that can indicate allergic reactions or the presence of worms

Other Rare Side Effects

Fever, nausea, vomiting, genital infection and headache are considered unusual reactions for this antibiotic but should be taken care of if they occur and should be reported to your doctor.

There are records of people who’ve experienced severe anemia, along with pallor, tiredness and shortness of breath, while using the drug. In this case, the use of Ceftriaxone should be ceased immediately and the anemia treated. Other rare side effects include pancreatitis of biliary origin, urticaria, inflammation of the intestine, presence of blood in the urine, chills and edema. If any of these side effects occur, you should consult your doctor immediately. 

Although diarrhea is considered a common side effect of the drug that can often be treated at home, it’s necessary to seek medical help if the condition is persistent or excessive.

How to Use Ceftriaxone

Ceftriaxone injections must be administered by a healthcare professional. The number of treatments and treatment durations are determined by the doctor and usually depend on how effective the antibiotic treats the specific infection.

It’s important to continue the full prescribed treatment when using Ceftriaxone and other antibiotics, even if symptoms dissipate. Discontinuing treatment can result in a resurgence of the infection with higher resistance to antibiotic treatments. 

If your infection worsens or doesn't improve, it’s crucial to inform your doctor immediately.

Other Considerations With Ceftriaxone

People with allergies to penicillin or other components present in Ceftriaxone should not use this antibiotic. Pregnant or breastfeeding women should also avoid it unless authorized by a doctor.

Is Ceftriaxone a Powerful Antibiotic?

Ceftriaxone is what’s known as a broad-spectrum antibiotic, indicating that it works against a large number of different bacteria. Other antibiotics can treat more serious infections, but Ceftriaxone works on many mild to moderate infections caused by a variety of bacteria.

Christian Worstell
About the Author

Christian Worstell is a senior Medicare and health insurance writer with He is also a licensed health insurance agent. Christian is well-known in the insurance industry for the thousands of educational articles he’s written, helping Americans better understand their health insurance and Medicare coverage.

Christian’s work as a Medicare expert has appeared in several top-tier and trade news outlets including Forbes, MarketWatch, WebMD and Yahoo! Finance.

While at HelpAdvisor, Christian has written hundreds of articles that teach Medicare beneficiaries the best practices for navigating Medicare. His articles are read by thousands of older Americans each month. By better understanding their health care coverage, readers may hopefully learn how to limit their out-of-pocket Medicare spending and access quality medical care.

Christian’s passion for his role stems from his desire to make a difference in the senior community. He strongly believes that the more beneficiaries know about their Medicare coverage, the better their overall health and wellness is as a result.

A current resident of Raleigh, Christian is a graduate of Shippensburg University with a bachelor’s degree in journalism. You can find Christian’s most recent articles in our blog.

If you’re a member of the media looking to connect with Christian, please don’t hesitate to email our public relations team at

Read More
Man Meets With Insurance Counselor
Where can you find the best Medicare Part D prescription drug plans of 2024? We review some of the ...
Pharmacist holds prescription for patient and smiles
Search the Wellcare Medicare drug formulary to find out if your prescriptions are covered by a Wellcare ...
A woman holds a prescription bottle while speaking with her pharmacist
The Humana Medicare drug formulary guide allows you to find out which Humana Medicare drug plans cover ...