Linzess for Relief of Constipation and IBS Symptoms

Christian Worstell
In this article...
  • Linzess can help soothe the symptoms of IBS, including chronic constipation. Find out how this medication works and whether it might be right for you.

Linzess is a prescription medication used to treat irritable bowel syndrome (IBS) and chronic constipation. It comes in an oral capsule formulated for once-daily use and does not have a generic version. 

How Does Linzess Work?

Linzess increases the amount of fluid in your intestines to help matter and waste flow through the system. Some studies show it may also soothe the nerves in the bowel area to reduce discomfort associated with IBS and related conditions that cause constipation.

You should take Linzess first thing in the morning on an empty stomach. Wait at least half an hour after taking the medication before consuming food. The capsule should not be broken or chewed, but it can be mixed with water or applesauce as long as you drink the mixture immediately. If you miss your dose, do not take another dose. Wait until the next day and take the capsule at your regular time.

How Long Does It Take for Linzess to Work?

After 7 days of taking Linzess, most people experience constipation relief. With continued use, symptoms usually improve, as Linzess works most effectively after the 12-week mark.

Linzess Side Effects

Some people may experience cold symptoms, diarrhea or stomach pain while taking Linzess. However, most adults prescribed this drug can take it without issues.

In children ages 18 and younger, Linzess can result in serious dehydration and is unsafe to use. Call your healthcare provider right away if you have severe diarrhea or signs of dehydration such as extreme fatigue, difficulty urinating, loss of consciousness or dizziness while taking this medication.

Does Medicare Cover Linzess?

Medicare typically covers Linzess if you have prescription drug coverage through your Part D or Advantage plan. However, you must meet your deductible first. Medicare Part D deductibles can be a maximum of $545 in 2024. 

Christian Worstell
About the Author

Christian Worstell is a senior Medicare and health insurance writer with He is also a licensed health insurance agent. Christian is well-known in the insurance industry for the thousands of educational articles he’s written, helping Americans better understand their health insurance and Medicare coverage.

Christian’s work as a Medicare expert has appeared in several top-tier and trade news outlets including Forbes, MarketWatch, WebMD and Yahoo! Finance.

While at HelpAdvisor, Christian has written hundreds of articles that teach Medicare beneficiaries the best practices for navigating Medicare. His articles are read by thousands of older Americans each month. By better understanding their health care coverage, readers may hopefully learn how to limit their out-of-pocket Medicare spending and access quality medical care.

Christian’s passion for his role stems from his desire to make a difference in the senior community. He strongly believes that the more beneficiaries know about their Medicare coverage, the better their overall health and wellness is as a result.

A current resident of Raleigh, Christian is a graduate of Shippensburg University with a bachelor’s degree in journalism. You can find Christian’s most recent articles in our blog.

If you’re a member of the media looking to connect with Christian, please don’t hesitate to email our public relations team at

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