Does Medicare Cover ENTYVIO?

Christian Worstell
In this article...
  • If you were prescribed ENTYVIO, you may be wondering if your Medicare plan or supplemental policies cover it. Find out more about this drug and whether Medicare covers it now.

ENTYVIO is also known by the chemical name vedolizumab and is typically administered via an IV infusion in a clinic or hospital. Administration takes around 30 minutes and is generally done at 2 and 6 weeks following your initial dose. After 6 weeks, maintenance doses are usually given every 2 months or 8 weeks.

Both brand name and generic options are available, but access often depends on where you receive your treatment.

If you've been prescribed ENTYVIO, you're probably wondering if Medicare covers it. 

Does Medicare Cover ENTYVIO?

ENTYVIO isn't covered by either Medicare Part D or the drug benefit of your Medicare Advantage plan because it's a drug that is typically injected by a healthcare provider in an office setting. This means that it may be covered under Medicare Part B or your outpatient Medicare Advantage benefits. 

Discuss your coverage and whether your provider can bill Medicare for this treatment. If you haven't met your Part B deductible, you will have to pay it before coverage kicks in.

As of 2024, the Part B deductible is $240. After you meet the deductible, you may be responsible for 20% coinsurance for all charges Medicare approves; if you have supplemental insurance, it may pick up some or all of that coinsurance amount.

What Is ENTYVIO Used For?

ENTYVIO is used to treat moderate to severe Crohn's Disease (CD) and Ulcerative Colitis (UC) in adults. It's a last resort for people who haven't been able to manage their symptoms using other medical therapies and medications. While usually very successful in treating UD and UC, ENTYVIO can be expensive and comes with several severe potential side effects. 

Potential Side Effects

Potential side effects of using ENTYVIO IV infusions include:

  • Headaches
  • Joint pain
  • Pain in the extremities
  • Cold and flu
  • Hypersensitivity
  • Allergic reactions 
  • Infusion-related reactions
  • Infections
  • Liver injury
Christian Worstell
About the Author

Christian Worstell is a senior Medicare and health insurance writer with He is also a licensed health insurance agent. Christian is well-known in the insurance industry for the thousands of educational articles he’s written, helping Americans better understand their health insurance and Medicare coverage.

Christian’s work as a Medicare expert has appeared in several top-tier and trade news outlets including Forbes, MarketWatch, WebMD and Yahoo! Finance.

While at HelpAdvisor, Christian has written hundreds of articles that teach Medicare beneficiaries the best practices for navigating Medicare. His articles are read by thousands of older Americans each month. By better understanding their health care coverage, readers may hopefully learn how to limit their out-of-pocket Medicare spending and access quality medical care.

Christian’s passion for his role stems from his desire to make a difference in the senior community. He strongly believes that the more beneficiaries know about their Medicare coverage, the better their overall health and wellness is as a result.

A current resident of Raleigh, Christian is a graduate of Shippensburg University with a bachelor’s degree in journalism. You can find Christian’s most recent articles in our blog.

If you’re a member of the media looking to connect with Christian, please don’t hesitate to email our public relations team at

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